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Cabergoline is indicated for second-line therapy in patients who are intolerant or fail treatment with a non-ergot compound, as monotherapy, or as an adjunctive treatment to levodopa and a dopa-decarboxylase inhibitor in the management of Parkinson's disease. Dosage High levels of prolactin occur in people with prolactinomas. A prolactinoma is a non-cancerous swelling in the pituitary gland. This can cause various symptoms including reduced fertility, breast changes, and headaches. Prolactinomas can be treated successfully with medicines which reduce the production of prolactin, such as cabergoline. In these cases, treatment is usually long-term. Cabergoline is indicated for the treatment of dysfunctions associated with hyperprolactinaemia, including amenorrhoea, oligomenorrhoea, anovulation and galactorrhoea. Cabergoline is indicated in patients with prolactin-secreting pituitary adenomas (micro- and macroprolactinomas), idiopathic hyperprolactinaemia, or empty sella syndrome with associated hyperprolactinaemia, which represent the basic underlying pathologies contributing to the above clinical manifestations. have swelling of the hands and feet and a high blood pressure during pregnancy (preeclampsia, eclampsia) Ten days after administration about 18% and 72% of the radioactive dose was recovered in urine and faeces, respectively. Unchanged drug in urine accounted for 2-3% of the dose.
Raynaud’s disease (When it is cold the fingers and toes become bluish white, with no pulse, cold, insensitive and numb) Cabergoline is a tablet treatment used to reduce the production of a hormone called prolactin by the pituitary gland (a gland at the base of the brain). If you have a prolactinoma (overproduction of prolactin by a cluster of cells in the pituitary), cabergoline treatment is also used to shrink the size of the swelling on the pituitary gland. How should I take cabergoline? After oral administration of the labelled compound, radioactivity was rapidly absorbed from the gastrointestinal tract as the peak of radioactivity in plasma was between 0.5 and 4 hours.Sometimes people taking cabergoline can fall asleep suddenly with little or no warning of being tired beforehand. Until you know how you react, take extra care if you drive and if you operate machinery. If you do find yourself falling asleep suddenly, you should see your doctor as soon as possible for advice. Avoid driving and avoid use of tools and machines in the meantime. The safety and efficacy of cabergoline has not been established in subjects less than 16 years of age. Before you are given Cabergoline your doctor will arrange for you to have tests to assess the condition of your heart. Your doctor will continue to monitor your medical condition while taking Cabergoline. Martindale: The Complete Drug Reference, 37th edition (2011) ed. Sweetman, S. Pharmaceutical Press, London. Lower doses should be considered in patients with severe hepatic insufficiency (Child-Pugh Class C). Contraindications
Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk. Cabergoline generally exerts a hypotensive effect in patients on long-term treatment; Postural hypotension
Uses
Advise patients that side effects including excessive daytime sleepiness or sudden onset of sleep and hypotensive reactions may occur and that they should exercise caution when driving or operating machinery. They should be informed to refrain from driving or operating machinery until the effects have stopped recurring. blood problems including low blood count (symptoms may include tiredness), abnormal liver function tests A decrease in haemoglobin values have been observed in amenhorrheic women during the first few months after menses. If you have any of the following health problems you must inform your doctor before taking Cabergoline as the medicinal product may be unsuitable for you:
There are some much rarer side-effects of cabergoline. Very rare cases of heart valve damage have been reported. Usually your doctor will listen to your heart before starting cabergoline treatment, and they may arrange an echocardiogram heart scan. This scan may be repeated if you need long-term treatment. It is very unusual for cabergoline to cause clinically significant heart problems, but you should alert your doctor if you developed shortness of breath or ankle swelling.
5) how to store cabergoline
As Cabergoline will stop you from producing milk for your baby, you should not take Cabergoline if you plan to breastfeed. If you need to take Cabergoline you should use another method for feeding your baby. Nursing mothers should note that the quantity of milk can diminish. Inability to resist the impulse, drive or temptation to perform an action that could be harmful to you or others, which may include:
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